Abstract: FR-PO1112
COVID-19 Omicron Infections in a Chinese Peritoneal Dialysis Center
Session Information
- COVID-19 - II
November 03, 2023 | Location: Exhibit Hall, Pennsylvania Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Coronavirus (COVID-19)
- 000 Coronavirus (COVID-19)
Authors
- Chen, Jin, Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital, Sichuan Clinic Research Center for Kidney Diseases, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China
- Li, Guisen, Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital, Sichuan Clinic Research Center for Kidney Diseases, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China
Background
In December 2022, an outbreak of the COVID-19 Omicron variant occurred in China, resulting in widespread population transmission. Peritoneal dialysis (PD) patients, as a predisposed group, faced significant risks.The aim of this study was to investigate the outcomes and risk factors in peritoneal dialysis (PD) patients infected with COVID-19.
Methods
Demographic and clinical characteristics of 341 PD patients were recorded at admission. Both binary logistic regression analysis and Cox proportional hazard regression analysis were used to evaluate potential risk factors for infection and mortality.
Results
COVID-19 was confirmed in 260 (76.2%) patients. Among infected patients, 57 (16.7%) were hospitalized and 11 (4.2%) patients died. Old age (odds ratio [OR] 1.042, 95% confidence interval [95% CI] 1.010-1.075, p=.01), dyspnea (OR 6.113, 95% CI 2.268-16.475, p<.001), use of systemic glucocorticoids (OR 5.830, 95% CI 1.164-29.201, p= .03), baseline hyponatremia (OR 3.096, 95% CI 1.125-8.517, p=.03), and baseline high-sensitivity C-reactive protein (hsCRP) (OR 1.089, 95% CI 1.011-1.173, p=.02) were associated with hospitalization. Patients with a higher Charlson comorbidity index score (OR 2.143, 95% CI 1.094-4.198, p=.03), weight loss (OR 9.168, 95% CI 1.604-52.399, p= .01), and baseline hyponatremia (OR 19.345, 95% CI 2.229-167.862, p=.007) were more likely to die compared to survivors.
Conclusion
Older PD patients with dyspnea, in receipt of glucocorticoid therapy, and baseline hyponatremia had a higher risk of hospitalization. Charlson comorbidity index score, weight loss, and baseline hyponatremia were associated with mortality.