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Kidney Week

Abstract: INFO08-FR

The Kidney Precision Medicine Project (KPMP)

Session Information

  • Informational Posters - II
    November 03, 2023 | Location: Exhibit Hall, Pennsylvania Convention Center
    Abstract Time: 10:00 AM - 12:00 PM

Category: CKD (Non-Dialysis)

  • No subcategory defined

Authors

  • Himmelfarb, Jonathan, University of Washington School of Medicine, Seattle, Washington, United States
  • Kretzler, Matthias, University of Michigan Michigan Medicine, Ann Arbor, Michigan, United States

Group or Team Name

  • KPMP
Description

The Kidney Precision Medicine Project (KPMP) is a National Institute of Diabetes and Digestive and Kidney Diseases funded consortium that aims to better understand and treat human kidney diseases. The goals of KPMP are to ethically and safely obtain kidney biopsies from participants with diagnosed acute kidney injury (AKI) or chronic kidney disease (CKD), to find disease subgroups to better stratify kidney disease patients, to identify critical cells pathways and targets for novel therapies, and to create a kidney tissue atlas.

KPMP recently began its second funding cycle. Currently, over 40 sites make up the consortium, including eleven sites that serve as AKI or CKD recruitment & biopsy centers, and seven multi-site tissue interrogation centers that analyze the biopsy tissues through a combination of imaging, transcriptomic, proteomic and metabolomic technologies. In the first funding cycle, The KPMP Opportunity Pool funded 27 projects to serve as key enhancers and accelerators for the success of the consortium. Coordination of study activities is led by several sites in a federated Central Hub. Central Hub responsibilities include administrative organization and data coordination. Data integration and visualization is overseen by the Kidney Mapping Atlas Project (KMAP). Patient engagement is paramount to the work of the consortium; kidney patients advise on all study activities by serving on the KPMP Community Engagement Committee, as well as other consortium committees, including the Steering Committee.

KPMP by design is a publicly available resource to both research and lay communities. The KPMP website www.kpmp.org is a gateway to access all study resources, including protocols and the kidney tissue atlas. Non-identifiable data for the 200+ biopsied participants is made available to the research community immediately after quality control, annotation, and validation at www.atlas.kpmp.org. There are currently over 4000 datasets available to the research community, as well as several tools available to help researchers understand KPMP data. Funded collaboration opportunities are periodically available through RFAs on the study website. The consortium is now accepting ancillary study applications and anticipates whole genome sequencing data to be available in the near future.

Funding

  • KPMP Is supported by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).