Abstract: TH-PO1150
Effect of Curcumin on Vascular and Cognitive Function in CKD: A Randomized Controlled Trial
Session Information
- Late-Breaking Posters
November 02, 2023 | Location: Exhibit Hall, Pennsylvania Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: CKD (Non-Dialysis)
- 2302 CKD (Non-Dialysis): Clinical, Outcomes, and Trials
Authors
- Gimblet, Colin J., The University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa City, Iowa, United States
- Kruse, Nicholas T, Central Michigan University, Mount Pleasant, Michigan, United States
- Geasland, Katharine M., The University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa City, Iowa, United States
- Michelson, Jeni, University of Iowa Hospitals and Clinics, Iowa City, Iowa, United States
- Sun, Mingyao, The University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa City, Iowa, United States
- Ten Eyck, Patrick, The University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa City, Iowa, United States
- Sambharia, Meenakshi, The University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa City, Iowa, United States
- Rossman, Matthew, University of Colorado Boulder, Boulder, Colorado, United States
- Linkenmeyer, Carinda, The University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa City, Iowa, United States
- Tamura, Manjula, Stanford University, Stanford, California, United States
- Chonchol, Michel, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States
- Seals, Douglas R., University of Colorado Boulder, Boulder, Colorado, United States
- Hoth, Karin, The University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa City, Iowa, United States
- Jalal, Diana I., The University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa City, Iowa, United States
Background
Chronic kidney disease (CKD) increases the risk of developing cardiovascular disease (CVD) and cognitive impairment. Curcumin is a polyphenol that has been reported to improve vascular and cognitive function in middle-aged and older adults, however its effects on vascular and cognitive function in patients with CKD are unknown. We hypothesized that 12-month curcumin supplementation would improve vascular and cognitive function in patients with CKD.
Methods
88 adults with CKD (stage 3B or 4) participated in a 12-month, randomized, double-blind, placebo-controlled, parallel-arms intervention to examine the effects of curcumin (Longvida, 2000 mg/day) on vascular and cognitive function. Our primary outcomes were endothelial function and aortic stiffness determined from brachial artery flow-mediated dilation (FMD) and carotid-femoral pulse wave velocity (cfPWV), respectively. Our secondary outcomes were endothelium- independent dilation via nitroglycerin mediated dilation and cognitive function assessed via the NIH Toolbox Cognition Battery.
Results
75% of the participants were male, 56% had diabetes, and 15% had a history of CVD. The mean±SD age and eGFR were 66±8 years and 34.7±10.8 ml/min/1.73m2, respectively. The median (IQR) UACR was 81.9 mg/g (9.7-417.3). Following 12-months of curcumin supplementation, we observed no change in brachial artery FMD, nitroglycerin mediated dilation, or cfPWV (P>0.05; Table 1). Additionally, we observed no change in processing speed, executive function, memory, or language (P>0.05; Table 1). eGFR, UACR, hemoglobin A1c, and blood pressure were unchanged (P>0.05).
Conclusion
12-month curcumin supplementation did not change vascular or cognitive function in patients with CKD.
Change in primary and secondary outcomes according to study group
Variable | Curcumin | Placebo | P value |
FMD, % | -0.7 (-2.1,1.1) | -0.1 (-1.5,1.5) | 0.69 |
cfPWV, m/s | 0.3±2.4 | 0.4±4.2 | 0.94 |
Nitroglycerin dilation, % | -1.3±7.7 | -1.3±6.5 | 0.97 |
Processing speed* | -0.9±8.9 | 1.8±7.0 | 0.15 |
Executive function* | 2.6±9.0 | 2.3±9.5 | 0.86 |
Memory* | 2.2±9.2 | 2.6±8.5 | 0.83 |
Language* | -0.5±5.8 | -1.3±4.5 | 0.51 |
*Age-adjusted T-score
Funding
- Other NIH Support